There are several features making Drosophila as a feasible model system to study human diseases. First, it is a genetically tractable organism with sophisticated tools to test genes’ functions. More importantly, nearly 75% of human disease genes have a Drosophila homologue and the conservation in signaling pathways provide promising approaches to test or design new drugs. The most prevailing aspect of this model system is the capability to do whole genome-wide forward genetic screen to seek for novel genes contributing to the pathogenesis of diseases. In our screen, we identified a few promising candidate genes, which might serve as novel potential targets for therapeutic design. Here, Drosophila oogenesis will be applied to study for cell migration and cancer metastasis. Ultimately, candidate genes identified in flies will be examined in mammalian cell lines or patient samples.