Dr. Yi-Ching Wang's laboratory has a long-standing research interest on the molecular mechanisms involved in lung tumorigenesis. Her group investigates the etiological association of alterations in tumor suppressor genes and oncogenes with lung tumorigenesis. Dr. Wang has continued to do research on cancer genomics and epigenomics of DNA methylation and chromatin alteration profiles for identification of new genes critical to lung tumorigenesis. More recently, Dr. Wang focuses on the role of Rab37 small GTPase in regulation of exocytosis and malfunction of Rab37 in tumorigenesis and tumor microenvironment. In addition, Dr. Wang's group identifies an oncogenic zinc finger transcription factor ZNF322A and investigates the underlying mechanisms of ZNF322A in cancer progression. Several potential anti-cancer drugs and antibodies also are developing in her laboratory.